Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid

Material Information

Title:
Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid
Creator:
Raju, Ravinder
Castillo, Bernard F., II
Place of Publication:
Bethesda, MD
Publisher:
The American Association of Immunologists, Inc.
Publication Date:
Language:
English
Physical Description:
pages 4122-4125 : illustrations (some color).

Subjects

Subjects / Keywords:
Glycolipid -- Synthesis -- Research

Notes

Abstract:
Four 3''- and 4''-deoxy and -fluorogalactosyl ceramides were synthesized, and their ability to stimulate iNKT cells, based on levels of IL-2 production, was assessed in three NKT cell receptor hybridomas. In two of the hybridomas, 1.2 and 2H4, all of the analogs were immunostimulatory, while in the 1.4 hybridoma only the 4''-fluoro analog led to the production of significant levels of IL-2.
General Note:
Published IN: Bioorganic & medicinal chemistry letters. Volume 19, no. 15 (2009 August 1).

Record Information

Source Institution:
University of the Virgin Islands
Holding Location:
University of the Virgin Islands
Rights Management:
All applicable rights reserved by the source institution and holding location.